Giacomo Garrè
Inverse Problem.
Started on November, 2022
Supervision: Dr. Alessandro Zunino (IIT), Prof. Federico Benvenuto (Unige) and Dr. Giuseppe Vicidomini (IIT)
Email
Short Bio
Giacomo Garrè obtained the BSc in Mathematics (2020) and the MSc in Applied Mathematics (2022) from the University of Genoa (Italy). Since November 2022, he undertook a Ph.D. scolarship in “Bioengineering and Robotics” at the University of Genoa to join the Molecular Microscopy and Spectroscopy laboratory of Italian Institute of Technology (IIT, Genoa) , under the supervision of Dr. Alessandro Zunino, Prof. Federico Benvenuto (Unige) and Giuseppe Vicidomini. His research interests include inverse problems, image processing and data-analysis applied to super-resolution microscopy.
Projects Description
Detector arrays make Image Scanning Microscopy (ISM) the natural successor of confocal microscopy. ISM enables super-resolution at an excellent signal-to-noise ratio. Maximizing photon budget requires large detectors and so more out-of-focus light is collected. The ISM dataset inherently contains information on the axial position of the fluorescence emitters. The aim of our project is to exploit such information to reassign the signal in the three dimensions, improving the signal-to-background ratio and resolution. Moreover, we enable image denoising by posing a statistical model on the arrival of photons on the SPAD array detector.